The characteristics of hand Verruca vulgaris in Tibetan adolescents in Ganzi county

Objective: To analyse the prevalence and characteristics about viral warts on the hands of Tibetan adolescents in Ganzi County.

Development of Flat Warts on the Cheeks after BioNTech-Pfizer BNT162b2 Vaccine: Is There a Correlation?

The SARS-CoV-2 pandemic has affected health systems across the globe, making the use of vaccines more urgent and topical than ever. Since the first months after the introduction of vaccinations, several reactions, both local and systemic, have been reported although they were mostly very mild and only rarely harbingers of more serious complications. We present a case of multiple flat warts onset over the cheeks in a patient after the second dose of mRNA BioNTech-Pfizer BNT162b2 vaccine, and we discuss the possible temporal association between the two events, also considering the patient's antibody status.

Antiviral potential of garlic (Allium sativum) and its organosulfur compounds: A systematic update of pre-clinical and clinical data.

BACKGROUND: Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its antiviral effects and the underlying molecular mechanisms exists. SCOPE AND APPROACH: The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. KEY FINDINGS AND CONCLUSIONS: Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections.

Flat warts self-cured in a patient after given COVID-19 vaccination: A case report

A 26-year-old male presented with flat warts for 2 years, and was given the treatment of retinoids and CO2 lattice laser, with poor therapeutic effect. The Patient was given COVID-19 vaccination (vero cell), Inactivated (Beijing Institute of Biological Products Co., Ltd, Batch Number: 2021020088) on May 13, 2021. The lesions colour turned red, and itching obviously after 1 day of vaccination. No treatment was given when the patient visited the doctor on May 17, 2021. The lesions subsided when the patient visited the doctor on May 23, 2021. © 2022 China Journal of Leprosy and Skin Diseases. All rights reserved.

Preventing human papilloma virus infection: another vaccination success

Human papillomavirus (HPV) is the commonest sexually transmitted infection. It has over 200 genotypes which, depending on the site of infection and type of virus, can give rise to cancers or warts. HPV infection is a prerequisite for cervical cancer and is associated to varying degrees with other anogenital cancers and, increasingly, with cancers of the oropharynx. It is also associated with anogenital warts which, while not life threatening, cause considerable morbidity. HPV vaccines have been available since 2006 and by mid-2021 have been introduced into over 110 countries. Trials and real world data have shown them to be safe and highly effective at preventing infection with HPV and anogenital warts. Data are also accumulating showing impressive reductions in cervical cancer. In UK, HPV vaccine mainly offered to girls and boys aged 12–13 years in a school-based programme. Uptake is generally high, but inequalities persist and there are concerns about the impact of a recent significant decline in uptake due to school closures arising from the COVID pandemic. HPV vaccine programmes have been significantly impacted by vaccine hesitancy in some countries, but experience in the Republic of Ireland and Denmark has shown that with involvement of the community, this can be successfully addressed. Modelling estimates that, by 2058, the vaccine will have prevented over 64,000 HPV-related cervical cancers and almost 50,000 other HPV-related cancers. The introduction of a vaccine containing nine HPV strains will further increase the number of cancers prevented. This short article outlines how HPV vaccination in adolescence is helping prevent serious illness in adult life.

Viral Cutaneous Infections in Swimmers: A Preliminary Study

Molluscum contagiosum (MC) and warts are common viral infections of the skin. Data regarding the prevalence of MC and verruca in swimmers are very poor and lacking in the literature. The purpose of this study was to determine the incidence of Molluscum Contagiosum (MC) and warts cases among young competitive swimmers participating in Greek swimming clubs. Of 244 swimmers enrolled in this study, 12.3% reported MC and 43% warts, during their swimming career, diagnosed and treated by dermatologists. There was no difference between sexes for MC but diagnoses of warts were higher in females. Axillae and trunk were the most common sites of primary infection for MC but warts mainly appeared on the soles. The incidence of MC and warts in swimmers who use outdoor facilities was higher. In our study, the incidence of warts and MC in Greek swimmers is considered high. Moist walking surfaces, placing towels on locker room benches, and sharing equipment are behaviors that cause infections. An early diagnosis of warts and MC lesions must be implemented in every swimmer through dermatological examination. Taking proper measures for reducing the risk of warts and MC transmission in Greek swimmers is mandatory.

Impact of reduced human papillomavirus vaccination coverage rates due to COVID-19 in the United States: A model based analysis.

The coronavirus disease 2019 (COVID-19) pandemic has significantly affected utilization of preventative health care, including vaccines. We aimed to assess HPV vaccination rates during the pandemic, and conduct a simulation model-based analysis to estimate the impact of current coverage and future pandemic recovery scenarios on disease outcomes. The model population included females and males of all ages in the US. The model compares pre-COVID vaccine uptake to 3 reduced coverage scenarios with varying recovery speed. Vaccine coverage was obtained from Truven Marketscan™. Substantially reduced coverage between March-August 2020 was observed compared to 2018-2019. The model predicted that 130,853 to 213,926 additional cases of genital warts; 22,503 to 48,157 cases of CIN1; 48,682 to 110,192 cases of CIN2/3; and 2,882 to 6,487 cases of cervical cancer will occur over the next 100 years, compared to status quo. Providers should plan efforts to recover HPV vaccination and minimize potential long-term consequences.

Clearance of longstanding treatment-resistant warts during COVID-19 in a transplant recipient.

Human papillomavirus (HPV), a DNA virus, infects basal keratinocytes and causes common warts and as well as malignancies of skin and mucous membranes. Although many treatment options are available, persistent HPV infections are common among transplant recipients. Herein, we present a patient with a 15-year history of treatment-resistant warts that regressed during COVID-19 (Coronavirus disease 2019) treatment.